Abstract: Taking pepper as test material, the resistance of 31 germplasm resources to anthracnose was studied by needle inoculation method, and the sensitivity of Colletotrichum scovillei to 19 drugs was studied by mycelial growth rate method, in order to provide reference for pepper resistance breeding and the application of drugs during the occurrence of anthracnose in Inner Mongolia.The results showed that among 31 germplasm resources, no high resistance variety was found, ‘C79-1-1’‘C167’‘Beixing No.9’ showed the moderate resistance to pepper anthracnose, accounting for 9.68%.Seven varieties namely ‘C169-1-1’‘Beixing No.5’‘C289’ ‘C168-1-1’ ‘C197’ ‘C252’ ‘C188’ were moderate susceptible, the other 21 varieties were all high susceptible to anthracnose disease.Among 19 fungicides detected, pyraclostrobin showed the highest control effect on C.scovillei,with EC₅₀ value as 5.966 7×10^-15 mg·L^-1,difenoconazole, prochloraz and tebuconazole also showed high control effect on C.scovillei,with EC₅₀ values as 1.583 3×10^-8 mg·L^-1,1.400 1×10^-7 mg·L^-1,2.838 7×10^-7 mg·L^-1.Fenaminosulf had the lowest inhibitory effect, with EC₅₀ value as 2 578.448 2 mg· L^-1,the EC₅₀ value of chloroisobromine cyanuric acid and metalaxyl·hymexazol were 978.523 9 mg·L^-1 and 76.794 8 mg·L^-1,which also showed very low inhibitory effect on anthracnose.