Abstract: In order to provide scientific basis for effectively preventing grape sourrot and black aspergilli and solving specific problems in production practice,the main cultivars of Sichuan Province and Yunnan Province were used as materials,supplemented by probiotics on the basis of conventional fungicides,to determine the control effect of grape sour rot and black aspergilli and its influence on fruit quality.The results showed that the probiotics could increase the size and 100-grain weight of grape fruit,and increase the sugar-acid ratio.The use of Lyukangwei on the basis of traditional fungicides had the best control effect on grape sour rot and black aspergilli,reaching 52.3% and 42.4% respectively.Using Lyudikang No.3 on the basis of conventional fungicides,the effect to control grape sour rot and black aspergilli were 31.3% and 21.9%.Both of the probiotics showed good control effect.The effects of chemical agents in the early stage and probiotics agents alone in the later stage were not obvious.