Abstract: Lonicera japonica is widely distributed in my country and has strong adaptability to the environment.It can maintain normal growth and development under a variety of stress conditions.It is a commonly used Chinese medicinal material with both economic value and ecological application value.The research progress of Lonicera japonica under stress conditions such as temperature, drought, light, salt, heavy metals and diseases, insect pests, endophytic bacteria, etc. were reviewed, and the current research situation of the physiological and biochemical response mechanism, changes of photosynthetic fluorescence and accumulation of secondary metabolites of Lonicera japonica under different stresses were discussed, in order to provide a reference for exploring the deep-level mechanism of Lonicera japonica resistance in the future, and at the same time, it was expected to lay a theoretical foundation for the ecological cultivation of high-quality authentic Lonicera japonica.