Abstract: Taking ‘Cricket Horn Honey’ melon seeds as the test material, treated with distilled water as control, and different concentrations(50,100,150,300,500 mg·L^-1) copper sulfate treatment of melon seeds were set, the number of germination, the conductivity of the extract, the root length, root volume, dry and fresh weight of the seedlings were measured.The germination rate, vigor index, root shoot ratio and other related indicators were calculated and analyzed.The effects of different concentrations of copper sulfate on the germination and seedling growth of melon seeds, in order to provide reference for the research and utilization of melon.The results showed that low concentration of copper sulfate could promote the germination of melon seeds, and higher concentration of copper sulfate had an inhibitory effect on the germination of melon seeds.When the concentration of copper sulfate was 100 mg·L^-1,the effect of promoting the germination of melon seeds was the best.At this time, the germination rate, plant dry and fresh weight, and root shoot ratio were 94.67%,0.014 6 g, 0.063 4 g, and 0.542 5,respectively, which were increased by 6.77%,5.80%,16.12%,11.46% compared with CK.When the concentration was 150 mg·L^-1,it had an inhibitory effect on seed germination.As the concentration of copper sulfate increases, the inhibitory effect strengthens.When the concentration of copper sulfate was 500 mg·L^-1,the inhibitoryeffect was the heaviest, and germination occurs at this time.The germination ratio, dry and fresh weight, root shoot ratio were 80.00%,0.012 5 g, 0.044 5 g, 0.404 6,respectively, which were 9.78%,10.07%,18.50%,16.87% lower than that of CK.The regression model was y=0.576 9x^{0.173 3},R~2=0.951 7.