Abstract: Four melon varieties including‘Jiashi Melon’‘Biceke’‘86-1’‘Kukebaire’were taken as test materials,a random block design were used to study the effects of saline-alkali（NaCl∶Na2 SO4 ∶NaHCO3∶ Na2 CO3 =9∶1∶1∶9,pH 10.80）stress on seed germination and plant growth,the concentration of saline-alkali solution was 50 mmol·L-1.The purpose of this study was to investigate the growth and development of the four melon varieties under the saline-alkali conditions and evaluate their salt tolerance,so as to provide a reference basis for melon cultivation in saline-alkali soil in southern Xinjiang.The results showed that the seed germination rate of four melon varieties was significantly lower than control group,the dry matter accumulation was also significantly reduced,the root length,plant height,leaf number,leaf weight and stem fresh weight were significantly reduced compared with the control group,at last,the photosynthetic parameters Pn,Gs,Tr and chlorophyll contents were also significantly decreased.Based on the above results,it could be seen that the combined saline solution of this concentration seriously inhibits the normal growth and development of melon.The saline-alkali tolerance of the four cultivars was different,‘Jiashi Melon’was a saline-alkali tolerant variety,and the saline-alkali tolerance of‘Biceke’was sensitive.