Abstract: Taking Vitis amurensis Rupr. pomace as the test material, using single factor and response surface tests, the effects of ultrasonic extraction time, ultrasonic extraction temperature, liquid-material ratio, and ethanol volume fraction on the extraction of anthocyanins from grape pomace were studied.The optimal extraction process of anthocyanins from Vitis amurensis Rupr. pomace has been optimized, in order to provide reference for extracting Vitis amurensis Rupr. pomace anthocyanins.The results showed that the optimized process conditions were an ultrasound-assisted extraction of Vitis amurensis Rupr. pomace anthocyanins.The optimal process conditions were ultrasonic extraction time of 21.20 minutes, ultrasonic extraction temperature of 37.64 ℃,liquid-material ratio of 15.62∶1 mL·g^-1,and ethanol volume fraction of 61.81%,under which the extraction yield of anthocyanins from Vitis amurensis Rupr. pomace was（0.358±0.005） mg·g^-1,and the error with the theoretical prediction value was only 0.56%.