Abstract: Eiatomace earths was used as experimental material,according to the guidelines foe crop safety evaluation of pesticides,the field plot trials were carried out by foliar spray.The safety on 25 times and 50 times and 100 times liquid of diatomite to the growth of Lycium barbarumin different varieties were explored,in order to provide reference for the application of diatomite earths in wolfberry production basis.The results showed that when diatomite earths will be used on different varieties of Lycium barbarum,more than 50 times liquid will be advised.It would not have any harmful effects about the growth of leaves and flower buds and branches.