Abstract: Four grape varieties, ‘Rizama’,‘Princess’,‘Yellow Rose’,and ‘Muscat hamburg’ were used as test materials, and calcium-zinc-boron, brassinolide, fulvic acid, and comprehensive treatment（calcium-zinc-Boron, brassinolide, fulvic acid） four treatment methods were set, the effects of nutrient elements and plant growth regulators on fruit cracking and fruit quality of different varieties of grapes were studied, in order to achieve the best prevention and control of grape cracking and improvement of fruit quality method.The results showed that the four treatments could reduce the fruit cracking rate and improve the fruit quality.Among them, the comprehensive treatment had the largest drop in fruit cracking rate compared with the control group of 58.34%-83.19%.Except for the ‘Rizama’,the comprehensive treatment had the largest increase rate in the horizontal diameter（3.41%-9.81%） and longitudinal diameter（3.46%-9.81%） of the control group.Except for the ‘Rizama’,the comprehensive treatment, calcium-zinc-boron treatment had the largest single fruit weight increase rate（12.10%-23.29%）,and the largest titratable acid decrease rate（2.90%-16.92%）.Except for the ‘Princess’,the comprehensive treatment and fulvic acid treatment have the largest increase rate of fruit hardness（17.61%-43.42%） and soluble solids（6.01%-15.20%）.The comprehensive treatment of the four varieties is more soluble than the control group.The increase rate of sugar content（16.80%-23.75%） and vitamin C content（1.16%-1.35%） is the largest.Principal component analysis showed that the four varieties were the best with comprehensive treatment and fulvic acid treatment.