Abstract: Taking Salvia miltiorrhiza from 50 collection sites in 14 cities in Shandong Province as experimental materials, the Maxent model and ArcGIS software were used, the effects of ecological factors on the distribution of Salvia miltiorrhiza in Shandong Province were studied by using the production suitability distribution method of Maxent model and ArcGIS software,in order to provide reference for the standardized cultivation of Salvia miltiorrhiza and the sustainable utilization of Salvia miltiorrhiza medicinal resources in Shandong Province.The results showed that the main ecological factors affecting the distribution of Salvia miltiorrhiza were precipitation in June,precipitation of wettest quarter,minimum temperature in July,and isothermality.The ecology suitable areas were eastern and central Shandong,including Linyi,Rizhao,Weifang,Zibo,Tai′an,Jining and Laiwu.According to the topography and geomorphology of the suitable area,it was divided into three major production areas.Tailai Mountain,Yimeng Mountain and Jiaodong Peninsula.