Abstract: The post-harvest glucose metabolism and the quality of oriental melon fruits on the five cultivars of oriental melons HGH188（yellow flesh）,19-B201（white flesh）,19-Q196（green flesh）,19-J251（orange flesh）,and 19-L270（green flesh） under long-term storage（at（23.2±2）℃） were studied, in order to provide reference for the high quality, durable storage oriemtal melon.The results showed that the fruits from HGH188 and 19-J251 were quickly softened and had lower shelf-stableness under an average storage time of 8 days.The taste was closely related to the fructose content in HGH188,19-Q196,and 19-B201 cultivars.During the average storage time of under 11 days, the activities of AI and NI in the 19-B201 fruit promoted the decomposition of sucrose into fructose and glucose, enriched the sugar composition, and made the flavor and taste of the 19-B201 fruit fuller.The fructose content in 19-Q196 fruit was synergistically regulated by the activity changes of SPS and AI;the taste of 19-L270 was closely related to the sucrose content in the fruit, and was comprehensively affected by the activity changes of SPS,AI,and NI.The average fruit water loss rate of 19-Q196 was the lowest, and the average storage time was 21 days, which was 6 days longer than that of 19-L270.The fruit sweetness, juice content, and fruit firmness of 19-Q196 and 19-L270 were kept at a high level during storage, and the storage resistance was better; the best flavor appreciation period of 19-Q196,19-B201 and 19-L270 was in 3 days.