Abstract: In order to enhance the added value of traditional Chinese herbal medicine polygonatum, a nutritious healthy meal replacement biscuit with a high satiety was developed. The optimal formula was determined by response surface methodology on the basis of single factor tests. The results showed that the best formula of polygonatum meal replacement biscuit was: low gluten flour 50.0 g, red bean powder 5.0 g, mung bean powder5.0 g, soybean powder 5.0 g, skim milk powder 5.0 g, chiya seed 2.0 g, stevioside 0.2 g, polygonatum powder4.5 g, maize germ oil 16.0 g, and meso-erythritol 10.0 g. Under these conditions, the prepared polygonatum meal replacement biscuits were rich in aroma and nutrition with a strong satiety after eating.