Abstract: In this paper, the Ganoderma lucidum spore powder was used as the main raw material. Based on the single factor experiment, the yield of Ganoderma lucidum polysaccharide was evaluated, and the best technology for extracting Ganoderma lucidum polysaccharide by cellulase extraction method was determined. And then the sensory score was evaluated with the main raw material as Ganoderma lucidum polysaccharide, the single factor and orthogonal experiments were used to optimize the formula of Ganoderma lucidum polysaccharide functional drink. In addition, the antioxidant activity in vitro of the drink was studied. The results showed that the optimal conditions for extracting Ganoderma lucidum polysaccharides by cellulase method are as follows: material-liquid ratio 1∶55（g/mL）, enzymolysis temperature 50 ℃, enzymolysis time 60 min, cellulase dosage 3%. Under the above conditions, the yield of Ganoderma lucidum polysaccharide was 2.89%. The optimal ratio of main auxiliary materials of functional drink to be 10% white sugar, 4% mango juice concentrate, and 0.2% citric acid. The results of scavenging free radicals in vitro showed that Ganoderma lucidum polysaccharide functional drink had good scavenging effects on DPPH·and OH·, and its half scavenging rate(IC₅₀) is 0.537 mg/mL and 0.650 mg/mL, respectively,and the total reducing power is up to 1.15%, which indicated that the product has antioxidant capacity, and has potential to be developed as health-care functional beverage.