Abstract: The extraction principle of Magnetic solid phase extraction（MSPE） and the preparation methods of magnetic adsorbents were reviewed. Also, the latest progress of MSPE application in safety detection of milk and dairy products in recent 5 ～6 years was reviewed in this paper. MSPE is mainly used in the detection of antibiotic residues, mycotoxins, persistent organic pollutants and plasticizers in dairy products. The commonly used methods of chromatography, mass spectrometry and chromatography-mass spectrometry for dairy products safety detection require high purity of the sample, and the pretreatment is complicated. As a pretreatment method, MSPE can separate the target analyte from the bulk sample by applying external magnetic field, which has the advantages of low detection limit, suitable recovery rate, simple operation, and fast and convenient process, so it has a wide application prospect.