Abstract: In high-density cage rearing mode, the living space of laying hens is limited, fatty liver syndrome and cage rearing fatigue occur in the late stage of laying, which leads to the decline of laying performance and egg quality. Moreover, the high content of pathogenic microorganisms in laying hens’ houses and multiple transmission channels in the field are easy to cause the occurrence and spread of disease. In addition, the abuse of disinfectants can cause problems such as drug residues and bacterial resistance. It not only increases the cost and difficulty of epidemic prevention in chicken farms, but also causes ecological pollution and food safety problems. The development of welfare farming improves the resistance and health status of laying hens. At the same time, green and efficient environmental purification technology is used to improve the breeding environment and cut off the transmission path of pathogenic microorganisms, which provides an important way for the healthy, safe and efficient production of laying hens. From the perspective of safety production technology application of laying hens, this paper summarized a new large cage aviary unit system technology of laying hen welfare and a green and efficient environmental purification technology based on slightly acidic electrolyzed water.The new large cage aviary unit system provided sufficient activity space and welfare facilities for laying hens,which could improve the adaptive ability of breeding hens to transfer population and meet the natural behavior expression of laying hens such as habitat, hidden egg production and claw grinding. It could significantly reduce serum alkaline phosphatase, liver weight and abdominal fat weight and improve the production performance,welfare level and health status of laying hens, which promoted the healthy, safe and efficient production of laying hens. At the same time, the traditional concept of biosafety prevention and control was changed. The slightly acidic electrolyzed water technique was applied in the disinfection of the indoor air and the surface of the equipment to improve the indoor environment. And it was also applied in the disinfection of the vehicles and personnel in entry and exit raise area and in the depuration of the exhaust air of poultry house to cut off the transmission path of pathogenic microorganisms. The objective of this summary was to provide a new way to improve the level of biosafety prevention and control in the laying hens farm and promote the safety production of laying hens.