Abstract: This study investigated possible mechanisms for sarcopenia treatment from mango leaves by using network pharmacology. Potential therapeutic targets of mango leaves were derived from TCMSP database, while targets for sarcopenia were derived from the GeneCards DisGeNET database. The PPI networks were generated by Cytoscape and core targets were identified through topological analysis. To identify potential targeting pathways, core targets were further introduced into the DAVID platform for GO and KEGG analyses. Finally, a total of 25 main components were screened and seven core targets were identified. Key pathways involved in hepatitis B, interleukin-17, and other signaling pathways and 25 main components were selected. Seven core targets were eventually identified, which were identified as potential therapeutic targets. Molecular docking results showed that quercetin had good binding ability with serine/threonine protein kinase-1, matrix metalloproteinase-9,tumor suppressor gene P53, and caveolin-1. Mango leaves had the potential to treat sarcopenia by regulating apoptosis and anti-inflammatory effects. This study had laid the foundation for further drug development and pharmacological experiments to treat sarcopenia.