Abstract: It is inevitable to design the opening structure of large aircraft, and the deformation of the large opening of the nose with curvature shape is more prominent. In this paper, a large aircraft nose boarding door frame is taken as the research object, the orthogonal test method is used to obtain the main factors and secondary factors affecting the deformation of the door frame and the changes of the door frame deformation with the moment of inertia of each component, which provides the design guidance for the stiffness design of similar large opening structures.