Abstract: Aiming at the problem that the first order vertical resonance frequency of the vertical expansion table of electric vibration table is low, this paper takes a vertical expansion table as the research object, and uses the finite element software to establish the finite element model of the vertical expansion table. The radius of the inner circle of the hollow cylinder, the height of the skirt, the distance from the skirt to the center of the table and the installation radius at the bottom of the table are taken as the optimization parameters. The input matrix and the verification matrix of the response surface fitting are constructed through different experimental designs. Finally, the structural parameters of the vertical expansion table are optimized by using the global response surface method. The results show that the first order vertical resonance frequency of the optimized vertical expansion table is increased from 2132.98Hz to 2185.21Hz, which verifies the effectiveness of the optimization method. The method has certain reference significance for the optimization design of other mesas.