Abstract: A thermal-vibration combined test system is established for typical titanium alloy skin and support structures, and comparative test of structural vibration fatigue life is carried out in high temperature environment. The effects of three different configurations of support structures and two different connection forms on the vibration fatigue life of titanium alloy skin and support structures are compared. The test results show that the typical structures with different support configurations have different vibration fatigue failure modes and life in high temperature environment. The typical structures with the same support configuration has different vibration fatigue performance in high temperature environment due to the different connection forms. The comparative test results can provide reference for the design of titanium alloy skin and support structures.