Abstract: 【Objective】The aim of the study was to investigate the effect of partial substitution of chemical fertilizers with organic fertilizer on potato growth.【Method】Seven different fertilizing treatments were carried out in the study,i.e.,no fertilization （CK）,100%conventional fertilization （T₁）,80% conventional fertilization （T₂）,80% conventional fertilization+solid organic fertilizer+organic liquid fertilizer （T₃）,80%conventional fertilization+solid organic fertilizer+micro fertilizer （T₄）,80% conventional fertilization+solid organic fertilizer+micro fertilizer+organic liquid fertilizer （T₅） and 80% conventional fertilization+solid organic fertilizer （T₆）,followed by the analysis on physiological characteristics,yield,dry matter and quality of potatoes.【Result】The partial replacement of chemical fertilizer by organic fertilizer promoted the above-ground growth of plants,and the number of branches and tubers in T₅ treatment increased by 26.38% and 108% when compared with T₁.The yield was the highest in T₅,which was 47729.7 kg/hm~2.The dry matter content was the highest in tubers of T₅ at maturity stage.The activities of superoxide dismutase,peroxidase and catalase in leaves with T₅ treatment were increased by 11.04%,31.63% and 95.72% when compared with T₁ treatment.The soluble protein content,reduced sugar,starch and VC content in the tubes of T₅ treatment were higher than those of other treatments,and the effect on potato quality was significantly different.【Conclusion】It was suggested that the fertilizer application of 80% conventional fertilization+solid organic fertilizer+micro fertilizer+organic liquid fertilizer could be recommended as the suitable method of fertilization in potato cultivation in this region.