Abstract: 【Objective】 The study aimed to explore the potential targets and molecular mechanism by which each individual Chinese medicine such as Codonopsis Radix and Atractylodis Macrocephalae Rhizoma in Fuyuan Hezhong Ointment plays a role in improving functional dyspepsia（FD）,with network pharmacology and molecular docking technology.【Method】 The progress on the researches of individual Chinese medicine in Fuyuan Hezhong Ointment improving FD were reviewed. The network of “FD-targetactive compound-Fuyuan Hezhong Ointment” was established. The related pathways of core targets were analyzed by GO,KEGG and molecular docking.【Result】 There are 10 out of 14 individual Chinese medicines from Fuyuan Hezhong Ointment,which have an effect in improving FD,and the main mechanism was to regulate the level of gastrointestinal hormone. Network pharmacology analysis indicated that there were 149 active components and 2 641 targets related to FD in Fuyuan Hezhong Ointment. There were 281 intersecting targets between Fuyuan Hezhong Ointment and FD. The top 5 core targets were obtained by PPI network screening. The top 25 active components in Fuyuan Hezhong Ointment were screened by performed the internet of “FD-target-active compound-Fuyuan Hezhong Ointment”. The analysis on 281 intersection targets by GO and KEGG showed that Fuyuan Hezhong Ointment might improve FD by means of cancer pathway,PI3K-Akt,MAPK and so on. The results of molecular docking showed that the 2 main active components（i. e.,quercetin and kaempferol） had good affinity with the top 3 core targets（i. e.,AKT1,TNF and IL-6）.【Conclusion】 The main active components（quercetin and kaempferol） in Fuyuan Hezhong ointment may act to improve FD through cancer pathway and PI3K-Akt,MAPK signaling pathways and through the targets of AKT1,TNF and IL-6.