Abstract: 【Objective】 The aim of this study was to investigate the potential for tomato leaf miners to feed on and transition to harming potatoes,leading to the development of a scientifically sound strategy for field control of this pest.【Method】 Two host plants,tomato（LycoPersicon esculentum） and potato（Solanum tuberosum）,were chosen to examine the developmental timeframe and survival rate of tomato leaf miners after feeding on different hosts. The activities of carboxylesterase,cytochrome P450,and glutathione Stransferase were assessed at 12 hours,24 hours,and 48 hours post-feeding.【Result】 The larval developmental period,adult lifespan,and larval survival rate of tomato leaf miners were significantly higher than those of potato leaf miners（P＜0. 05）. However,no variations were observed in the egg stage,pupal stage,pupal weight,female pupa ratio,egg hatching rate,emergence rate,and oviposition quantity. Following feeding on both host plants,the three detoxification enzyme activities of tomato leaf miners increased after consuming potato leaves and decreased after consuming tomato leaves,with potato leaf miner enzyme activities surpassing those of tomato leaf miners.【Conclusion】 Feeding on tomatoes favored the growth of tomato leaf miners,indicating a greater affinity of tomato leaf miners for tomatoes over potatoes. Post-feeding on the two host plants,variations in the activity levels of different detoxification enzymes in tomato leaf miners were observed,reflecting a correlation with host plant feeding preferences. Host plants with higher feeding suitability exhibited minimal changes and lower detoxification enzyme activity levels,while those less suitable experienced rapid changes and higher enzyme activity levels.