Abstract: Animal Genetics course is a required professional basic course in animal science majors of animal-agriculture-related colleges and universities, with lots of teaching contents, theories and abstract concepts. The traditional teaching mode is difficult to improve the classroom effect and stimulate students’ learning interest. In order to further improve the quality of teaching, the teaching team of Animal Breeding ＆ Genetic of Heilongjiang Bayi Agricultural University has carried out the reform and innovation of teaching. Relying on the online course resources of South China Agricultural University, the course team constructed an online-offline blended teaching mode of Animal Genetics through the integration of“Rain Classroom + BOPPPS”. The results showed that both the effectiveness of teaching reform of Animal Genetics course and teacher-student interaction throughout the whole process of “before, during and after class”were achieved; The integration of science and education reshaped teaching content and made theoretical materials concrete and vivid. It could be concluded that online and offline blended teaching practice of Animal Genetics based on“Rain Classroom + BOPPPS” science and education integration would be effective in improving students’ scientific literacy and stimulating students’ interest in learning, and effectively improving the quality of teaching.