Abstract: In recent years, researching on microorganisms has increasingly focused on microbial natural products, but few researchers have conducted a comprehensive review this field. In order to provide an intuitive reference for researchers, this study conducted statistical and bibliometric analysis on the papers published in Web of Science（core database） and CNKI database since 1974 about microbial natural products by Citespace and VOSviewer software to analyze the field of microbial natural products. The results showed that the research on microbial natural products had entered a stage of rapid development since 2012, and the total number of published papers has shown a rapid growth trend. According to Bradford′s law, it was found that the distribution of papers in this field were relatively scattered in diverse journals. According to Price′s Law, the core authors of Chinese and English literatures were those who had published no less than 2 and 3 papers respectively. The researchers in European countries had the most frequent cooperation, and there was a clear characteristics of clustering for Chinese scholars, which also actively participated in international cooperation. Based on the high-frequency keyword and co-occurrence graphs, there were obviously different characteristics in China and abroad for the current research levels, strategies, content, and hotspots. According to the above analysis, it is suggested that countries, research institutions, and researchers strengthen cooperation and applied research to promote the development of microbial natural product field.