Abstract: In order to explore the period and effect of integrated prevention and control on Northern maize leaf blight and main insect pests,field trials conducted in 2018-2019.The results showed that in the maize large bell period,spraying at the beginning of Northern maize leaf blight,this period was also the beginning of the occurrence of the young Ostrinia furnacalis larvae and Monolepta hieroglyphica adults.The control effect of azoxystrobin·propiconazole 18.7% SE 900 mL·hm^-2+ Chlorantraniliprole 5% SC on Northern maize leaf blight was greater than 80%,the control effect on Ostrinia furnacalis was greater than 85%,the control effect on Monolepta hieroglyphica was greater than 70%,prevention and control move forward,one spray,multiple defense,integrated prevention and control on main maize diseases and insect pests.