Abstract: Sclerotinia-derived stem rot disease,aglobal plant disease,endangers a variety of cash crops and results in seriously economic losses.Recently,there are some advances in pathogenic mechanisms and control of sclerotinia-derived stem rot disease.Combined with the existing literatures,we reviewed the advances on crop sclerotinia-derived stem rot disease from three aspects,（1）Pathogens and symptoms,including Sclerotiniaand Stromatinia which infect different plants respectively.（2）Pathogenic mechanisms,including finding the key genes or regulators of plant resistance to sclerotinia-derived stem rot disease,developing and utilizing resistance-related genes of plants to obtain broad-spectrum and long-lasting disease-resistant varieties.（3）Biocontrol of sclerotinia-derived stem rot disease,mainly focusing on a large number of microorganisms including bacteria,fungi and actinomycete with application potentials.The future on beneficial microbial resources and functions was prospected.