Abstract: The more frequent occurrence of fungal soilborne diseases led by Fusarium wilt in the process of shed production has irreversible effects on the quality and yield of melon, and greatly increases the cost of pastoral planning and cultivation management. Breeding varieties with comprehensive good traits through molecular breeding and disease biological control is the fundamental way to solve the melon disease crisis green and ecological. Based on the visualization analysis of knowledge map of VOSviewer, combined with the research hotspots and trends of melon Fusarium wilt since its first report in CNKI database, this paper reviewed the current research status of pathogen species and physiological characteristics of melon Fusarium wilt, melon resistance mechanism, resistance genes and resistance genetic rules, and expanded new research directions from the current research status.