Abstract: WRKY transcription factors are one of the largest gene family in plants. They are involved in plant response to biotic stress and abiotic stress and regulates the expression of corresponding genes. Some studies have shown that the signal transduction of ABA, SA, and JA were regulated by WRKY transcription factors. In order to gain a detailed understanding of the regulatory mechanisms of WRKY transcription factors in various plant hormone signal transduction pathways.This article focused on the positive and negative regulation of the ABA signal transduction pathway by WRKY transcription factors. The three regulatory modes of WRKY transcription factor on SA signal transduction-ICS pathway, PAL pathway, and binding cis acting elements.A review was presented on the two regulatory mechanisms of WRKY transcription factors on JA signal transduction: regulating JA biosynthesis genes and MYC2 mediated JA signaling pathways, with a view provide reference for further research on the regulatory mechanisms of WRKY transcription factors in complex plant hormone signal transduction processes.