Abstract: In order to further elucidate the occurrence mechanism of continuous cropping obstacles of flue-cured tobacco and scientifically selecting comprehensive prevention and control measures, hope for minimizing the continuous cropping obstacles of flue-cured tobacco and realizing the green, efficient and sustainable development of tobacco planting in China.The characteristics of continuous flue-cured tobacco soil were reviewed from the aspects of physical and chemical properties, enzyme activity, allelopathic substances and changes, microbial community structure and diversity in continuous flue-cured tobacco soil. The current prevention and control measures of continuous cropping obstacles of flue-cured tobacco in China were summarized from the aspects of cultivating resistant varieties, optimizing planting system, rational application of different kinds of fertilizer preparations, soil disinfection and biological control, and the future research direction and the latest development direction of prevention and control technology were prospected.