Abstract: Under the background of the new era, the construction of new agricultural science has become the important content of higher agricultural education reform in China. The major of seed science and engineering was a dominant discipline in the field of agriculture. By comparing with other dominant majors of agriculture, this paper analyzed the problems existing in the teaching of seed science and engineering courses in local agricultural colleges and universities. Aiming at the modern training goal of composite agricultural talents, it proposed to build a practical teaching system focusing on improving students’ practical and innovative ability, emphasizing comprehensivity and local characteristics. The online and offline mixed teaching mode was carried out, multiple practical teaching links was strengthen, curriculum comprehensive evaluation and other reform measures improved, and strive to continuously optimize the content of “industry-oriented practice, project-led practice, and exploratory practice”, build platforms for teachers and students inside and outside schools, and transfer platforms for senior teachers and young teachers, and explore new models of seed science and engineering practice teaching. The aim was to effectively improve the students’ professional quality and practical ability, and train more applied and innovative talents for modern agriculture.