Abstract: Pollution Ecology is a core course for undergraduates majoring in ecology.In order to better carry out the teaching of pollution ecology and improve the teaching quality,this paper took the ecology major of Northeast Agricultural University as an example,discussed the adjustment of the teaching content and teaching system of pollution ecology,and constructed the three-dimensional teaching mode of "theory+ practice+ ability".Among them,the teaching content took the migration and transportation of pollutants in organisms as the main line,and combined the impact of pollutants on organisms with the detoxification and adaptation of pollutants into a whole;the experimental content combines virtual simulation and indoor experiments.Through three years of teaching practice,the students’ theory of pollution ecology was more solid,their practical ability was improved,their holistic thinking of ecology was clearer,and the comprehensive goal of imparting knowledge,consolidating skills and improving ability was realized.