Abstract: Microbiology is an important requid course for life science majors, which exhibit basic, systematic and comprehensive. It involves a wide range of disciplines and has strong applicability. Strengthening the ideological and political teaching of microbiology is to meet the needs of teaching and curriculum ideological and political education. This paper expounded the necessity of developing the ideological and political education in the course of microbiology and explores the method of integrating the ideological and political elements into the classroom teaching of microbiology based on the mining and application of the cases of ideological and political education through the course. Ideological and political education was carried out during the course of teaching. It forms the synergy effect of professional curriculum and ideological and political education through knowledge teaching and value leading in parallel so as to achieve high-quality applied personnel training objectives.