Abstract: In order to promote the pollution-free production of pumpkin,natural ingredients were used as the main raw materials in this study.Osthole was mixed with the extracting solution of oleander flower and sophora flavescens at a volume ratio of 10∶1.5∶3.0 was used to prevent and control powdery mildew and gummy stem blight.The results showed that the control efficiency of the coplex plant-derived agents was more than 87%on powdery mildew and gummy stem blight fungus.In addition,the calculated synergistic coefficient values were all greater than 1 when the mixture was mixed with polyantimycin in the volume ratio of 10∶1 botanical fungicides.The plant pesticide developed in this experiment can replace chemical pesticide for disease control in the green production of seed pumpkin.