Abstract: In order to guide soybean production under potato and soybean rotation mode, three seed coating agents were selected to study the effects of different seed coating agents on agronomic characters and yield of soybean under different rotation mode. The results showed that the application effect of the three seed coating agents under potato and soybean rotation was better than that under soybean continuous cropping. Soybean seed dressing and coating promoted the growth and development of soybean plants, increased plant height, stem diameter, number of internodes, effective pods per plant, 100-seed weight and yield, reduced the height of bottom pods, promoted early podding, reduced the plant center of gravity, and resist lodging, at the same time promoted the occurrence of root nodules, and had obvious effects on the control of soybean root rot. Among them, the number of root nodules treated with compound microbial inoculants was the largest, and the effect of controlling soybean root rot was the best, which promoted the growth and development of soybean plants, promoted the effective podding and increased the yield; The number of harvested plants in the treatment of fine methyl-fluoxonitrile coating was the largest, but the control effect on root rot was the worst, and the incidence rate was the highest; The effective pod number, 100-seed weight and yield of Avi-do-Fu chemical treatment were the highest, and the yield increase effect was the best.