Abstract: In order to improve maize yield and nitrogen use efficiency, nitrification inhibitors and urease inhibitors are effective measures to regulate soil nitrogen transformation and control soil nitrogen loss in farmland. Through literature analysis, the inhibition mechanisms of commonly used nitrification inhibitors Nitrapyrin 2-chloro-6-（trichloromethyl） pyridine, DCD（Dicyandiamide）, DMPP（3,4-dimethylpyrazole phosphate） and urease inhibitor NBPT N-（n-butyl） thiophosphoric triamide were summarized, and the effects of nitrification/urease inhibitor combined with nitrogen application alone or in combination on maize yield, quality and nitrogen use efficiency were expounded. The analysis showed that the synergistic effect of nitrification/urease inhibitor combined application was obvious, which could prolong the nitrogen release cycle and promote the nitrogen absorption of maize. It could not only improve maize yield and nitrogen use efficiency, but also improve maize grain quality. In the future, it is recommended to strengthen research on application methods, impact mechanisms, and innovative processes for different ecological types and different soil types.