Abstract: Saline-alkali stress has a significant impact on rice development and productivity and is one of the leading causes of crop yield losses in agricultural productivity worldwide.CRISPR/Cas gene editing system is an efficient and simple gene editing technology,which has important application value in abiotic stress of plants.In this paper,we introduced the development process,classification and function of CRISPR/Cas gene editing system,as well as the response mechanism of rice to saline-alkali stress and reviewed the application of the CRISPR/Cas technology in developing saline-alkali tolerant rice varieties in recent years,and prospected its application prospect.