Abstract: In order to explore the facilitation role of “Entrepreneurship and Innovation Education” to the rural vitalization policy in our country, the paper explained the rural vitalization policy from the view of “ Entrepreneurship and Innovation Education” of agricultural university, taking exploration of educational practice of “Entrepreneurship and Innovation Education” in Jilin Agricultural Science and Technology University as example, the unique advantages and present situation of “Entrepreneurship and Innovation Education” in agricultural university to help rural vitalization was analyzed. The power assist mode of “Four Combinations” was put forward, such as “Farmers+Experts” mode promoting revitalization of talent, “Science and technology promotion+Information technology” promoting revitalization of science and technology, “Rural culture+Rural tourism” promoting revitalization of culture, “Scientific research projects+Rural livable ecology” promoting revitalization of ecology. The practice path of “Four Combinations” helping mode was figured out, including carrying out multi-form collaborative education mechanism and building practice education platform, constructing a new teaching model and improving the talent training system, guiding and helping “special” students group and encouraging their employment and entrepreneurship in the countryside, establishing effective incentive mechanisms and encouraging scientific research innovation. To sum up, agricultural universities shall adapt to the requirements of the times actively, deepen education reforming of “Entrepreneurship and Innovation Education” in the service of rural revitalization strategy and cultivate a batch of interdisciplinary, high-quality and applied agricultural talents for rural revitalization.