Abstract: The Frankliniella occidentalis（Pergande） is one of the most destructive pests of vegetables, fruits and ornamental crops throughout the word, harming plants by feeding directly on them and spreading a variety of viruses. Use of insecticides has been the primary strategy for controlling WFT, and insecticide resistance in WFT has been documented in a number of chemical classes. Therefore, in depth study of the molecular mechanism of resistance can provide an important theoretical basis for comprehensive management and green prevention and control of thrips WFT. This reviews introduced the progress on molecular mechanism of resistance of WFT to various insecticides, it mainly includes the functions of detoxification enzyme and transporter genes related to drug resistance, as well as the regulatory pathways of related genes, and puts forward feasible suggestions on the existing problems and looks forward to the future development direction of control of WFT.