Abstract: In order to improve the palatability and gastric irritation of tilmicosin, Eudragit L100 and Soluplus were used as the combined carrier to prepare tilmicosin ternary solid dispersion by spray drying method, and the phase identification was carried out by Fourier transform infrared spectroscopy; in vitro cumulative dissolution of tilmicosin ternary solid dispersion was investigated. The results showed that the prepared ternicosin ternary solid dispersion had a crystalline structure, and tilmicosin was dispersed in the carrier in an amorphous form. Tilmicosin ternary solid dispersion had a dissolution rate of 7.23% in acid at the 120 th minute, and a cumulative dissolution rate of 96.06% in buffer at the 45 th minute, which complied with the regulations for the dissolution of enteric-coated preparation in the first part of the 2015 edition of Chinese Veterinary Pharmacopoeia. The results suggested that the ternicosine ternary solid dispersion prepared in this study was simple and feasible, and effectively solved the palatability and gastric irritation problems of tilmicosin oral preparation.