Abstract: Good manufacturing practice for veterinary drug（the 2020 verision） is the more modified revision of the previous Good manufacturing practice for veterinary drug in China. There are great changes in terms of terms, text and chapter structure, and the overall content is more scientific, easier to operate and more instructive. Through comparative analysis of the newly released of Good manufacturing practice for veterinary drug（the 2020 version） and the 2002 version of Good manufacturing practice for veterinary drug, the author sorted out the concept of risk management and change control introduced, raised the requirement of some hardware facilities, upgraded and refined the software management and other aspects of the main changes and important measures in Good manufacturing practice for veterinary drug（the 2020 version）.Suggestions were put forward for enterprises to strengthen the study of Good manufacturing practice for veterinary drug（the 2020 version）, scientifically and rationally transform the hardware facilities, speed up the software upgrade, and actively and effectively promote the implementation of Good manufacturing practice for veterinary drug（the 2020 version） which provided reference for the understanding and implementation of Good manufacturing practice for veterinary drug（the 2020 version） for the manufacturers of veterinary drugs.