Abstract: Ultraviolet（UV）, which is invisible is a ray located outside the purple light in the spectrum. Exposure to UV light will induce a series of physiological changes in the animal body and affect its biological rhythm. In livestock production, most of the livestock production performance has annual or seasonal rhythm, and the rhythmic change of UV has an effect on the physiological state of animal skin. The skin is the barrier between the animal’s internal and external environment. The cycle, proliferation and apoptosis of skin cells are closely intertwined with the biological clock. The research progress of UV on skin-related gene expression regulation, DNA structure, gene transcription, protein translation and Wnt signaling pathway were reviewed. The mechanisms of UV maintaining physiological state of animal skin by affecting molecular regulatory network of animal tissue-cell-gene were analyzed, and the feasibility of using UV to regulate the production performance of livestock was explored, aiming to lay a solid theoretical foundation for how UV regulates physiological state of animal skin.