Abstract: In order to explore the mechanism of Forsythia and Lonicera japonica on the anti-influenza volatile oil, the network pharmacology method was used in the experiment.The chemical constituents of the volatile oil of Forsythia and Lonicera japonica were searched by literature retrieval; their targets were obtained through the Swiss Target Prediction database; the influenza-related targets were searched in the DisGeNET database; and the intersection targets of volatile oil and influenza were obtained on the Venny 2.1 online mapping tool platform; the volatile oil active component-anti-influenza target network map was constructed using Cytoscape 3.8 software.The STRING database was used to construct a protein interaction network map, and the core targets for the treatment of influenza were screened by topological parameters, and then GO enrichment and KEGG signaling pathway analysis were performed. The results showed that 30 active components of Forsythia and Lonicera japonica volatile oil and 59 targets related to influenza were screened, among which the core targets were IL-6, HSP90 AA1, CYP2 C19 and CCR5. GO enrichment and KEGG signal pathway analysis showed that the core targets were involved in various biological processes, such as the response to exogenous substances, the regulation of hormone levels, the response of cells to lipids, and the response to ammonium ions, acting on neuroactive ligand receptor signaling pathway, 5-serotonin synaptic signaling pathway, cAMP signaling pathway and cytokine interaction signaling pathway. The results suggested that the mechanism of multi-components, multi-targets and multi-pathways were involved in the treatment of influenza with volatile oil of Forsythia and Lonicera japonica.