Abstract:
A 12-year-old male Chow came to the doctor because of depression, a bulge of about 4 cm in diameter on the back of the neck, loss of appetite, and occasional cough. X-ray examination results of the dog were unremarkable. Subcutaneous puncture on the back of the neck showed a large number of red blood cells and a small increase in neutrophils. The results of blood cell count examination and serum biochemical index examination showed that the detection values of red blood cell count, hemoglobin content, hematocrit and total platelet count were all lower than the reference values. Subcutaneous dysplasia tissue was dark purple, hard and wrapped with cysts. The H.E. staining of abnormal hyperplasia tissue showed a large number of vascular cavities and vascular fissures, and the degree of differentiation gradually decreased toward the center. The tumor cells were massively aggregated with large and stained yellow brown. Cells were spindle-shaped, polygonal or oval. The results of immunohistochemistry showed that the positive staining rate of marker Ki-67 was about 30%. Comprehensive related examination results showed that the dog was diagnosed with cutaneous angiosarcoma. The results suggested that the clinical diagnosis methods of canine cutaneous hemangioma mainly included serum biochemical detection, chest and abdominal imaging examination, non-organ type effusion puncture examination, histopathological examination and immunohistochemical detection, among which immunohistochemical detection was accurate and reliable, and it was very important for the diagnosis of dogs and the selection of subsequent treatment.