Abstract: Phages are mainly used in the treatment of bacterial infection and have great advantages and application potential in the development of antibacterial drugs. However, phage therapy is affected by host spectrum stenosis, incomplete safety evaluation system and other factors, so the research progress as antibacterial drugs is slow. In recent years, the increase of multi-drug resistant bacteria has led to renewed interest in the use of phages as antimicrobial agents. The development of genetic engineering technology provides a wide range of possibilities for phage editing, so that phages can accurately detect and kill bacteria. This review discussed the progress of phage editing technology in order to provide a reference for phage therapy to play a greater role in clinical practice.