Abstract: Foot-and-mouth disease（FMD） is an acute and highly contagious livestock disease caused by Foot-and-mouth disease virus, which causes significant economic losses during the disease outbreak. When FMDV enters the host, it is recognized by the immune system, and type Ⅰ and Ⅲ interferons mediate an enhanced immune response. FMDV inhibits antiviral response through multiple pathways, including inhibiting the production of interferon at the transcriptional and translational level, hijacking, cleaving or interfering with the expression of host protein, blocking post-translational modification of proteins during natural immunity, regulating autophagy, and inhibiting the formation of stress granules（SGs）. This article reviewed the strategies against host immunity, in order to have a comprehensive understanding of the pathogenic mechanism of FMDV and provided a theoretical basis for the prevention and treatment of FMDV.