Abstract: In order to investigate the incidence of geese and common bacterial diseases in Hotan Prefecture of Xinjiang Uygur Autonomous Region, the experiment took 5 740 chicks from a goose farm in Hotan Prefecture as the research object. The daily morbidity and mortality of geese, clinical symptoms of sick geese, and pathological changes of dead geese were recorded for 21 consecutive days. 296 visceral samples of sick and dead geese were collected for bacterial isolation and identification; PCR amplification was used in specific primers to determine bacterial species. The results showed that the total incidence rate of geese was 95.73%, and the total mortality rate was 73.87%. There were 7 main clinical symptoms, namely diarrhea, neurological symptoms, diarrhea combined with neurological symptoms, bleeding from the mouth and nose, white and swollen eyes, swollen head, and swollen joints. There were 9 kinds of pathological changes, namely liver enlargement and congestion, yellowing of the liver, white spots on the liver, white nodules on the liver, pericarditis and perihepatitis, urate deposition, glandulogastric papilla bleeding, ascites, intestinal bleeding. A total of 240 bacterial strains were isolated from 296 visceral samples, with detection rates of 75.0%（222/296）, 4.4%（13/296） and 1.7%（5/296） for Escherichia coli, Proteus mirabilis and Salmonella, respectively, and 2.3%（7/296） for mixed infections. The results indicated that the morbidity and mortality rate of the goose farm were high, and the clinical symptoms were mainly diarrhea; the pathological changes were mainly liver enlargement and congestion; there were separate or mixed infections of E. coli, Salmonella and Proteus mirabilis, and the morbidity was complicated.