Abstract: Ciliate diseases of aquatic animals have the characteristics of high infection and mortality, and have caused serious economic losses to aquatic industry in China. Plant derived drugs have the advantages of low cost, easy degradation, little toxicity and abundant resources, and are increasingly used in the prevention and control of ciliate diseases in aquatic animals. In this paper, the application, effective components and mechanism of plant-derived drugs against aquatic ciliates were reviewed, the application prospect and development trend of plant-derived drugs in the prevention and treatment of ciliates in aquatic animals were prospected, in order to provide reference for the related research work of plant derived drugs.