Abstract: Trichinella spiralis disease is a zoonotic parasitic disease caused by Trichinella spiralis, which mainly attacks the intestinal tract and muscle tissue of the host. The intestinal infection stage of Trichinella spiralis refers to the adult stage of Trichinella spiralis, which is the key stage for Trichinella spiralis to invade the host, and determines whether the Trichinella spiralis has a complete life history in the host. Trichinella spiralis living in the intestine of host will cause a series of intestinal damage, and most of the Trichinella spiralis will be expulsed through the worm expulsion reaction of host. The expulsion reaction is the results of interaction by many factors, including the mucin secreted by intestinal epithelial cell and increase the peristaltic contraction ability of intestinal smooth muscle to promote the worm expulsion from the gut, both of which are regulated by humoral immunity and cellular immunity. The intestinal lesions, secretion of mucin, enhanced contractility of intestinal smooth muscle and immune regulation after infection with Trichinella spiralis was reviewed by the author. The aim of this study is to provide ideas for the study on the mechanism of Trichinella spiralis in intestinal infection.