Abstract: A 4-month-old female Ragdoll cat weighing 1.8 kg presented with high fever, defecate stool, sneezing, and coughing during the consultation period. The diagnosis of feline distemper was confirmed by routine blood test and Feline panleukopenia virus（FPV） test, and the cat was treated with antimicrobial anti-inflammatory, antiviral, symptomatic, and supportive therapies. On the 2nd day of treatment, the affected cat showed hoarse purring, absence of eyelid reflex in the left eye with transient membrane bulge, head deviation and other neurological symptoms; on the 3rd day, it took the initiative to eat a small amount of food, and the body temperature returned to normal; on the 5th day, the spirit, appetite, and fecal pattern returned to normal, and it was discharged from the hospital. On the 7th day after discharge, symptoms of vestibular nerve damage such as facial nerve paralysis and head deviation had not disappeared, and chronic otitis media and otitis media were diagnosed by computed tomography（CT） scanning; after 4 weeks of oral enrofloxacin treatment, neurological symptoms such as bulging of the third eyelid prominent and deviation of the head disappeared completely, and the walking posture returned to normal. The results suggested that this case was a case of otitis media secondary to feline panleukopenia, and enrofloxacin was effective in the treatment of otitis media in cats.