Abstract: Porcine epidemic diarrhea（PED） has high morbidity and mortality, especially since the emergence of highly pathogenic variant of Porcine epidemic diarrhea virus（PEDV）（GⅡ strain）. It is a huge threat to the global pig industry. After the virus infects the host, the host will activate the antiviral natural immune response mechanism. Interferon（IFN） is a kind of key molecule to resist virus infection, especially type Ⅰ interferon（IFN-Ⅰ）, which can prevent the proliferation of the opponent virus by activating various immune cells and co-stimulating molecules. At the same time, in order to achieve sustained replication in the host, many viruses have established a variety of molecular mechanisms to resist the IFN-Ⅰ response of the opponent host, and thus achieve immune escape. Many structural proteins encoded by PEDV can inhibit the immune response of the opponent host IFN-Ⅰ. In this paper, the molecular mechanism of PEDV structural protein antagonistic IFN-Ⅰ immune response was reviewed, in order to provide scientific reference for further elucidation of the molecular mechanism of PEDV immune escape and development of novel PEDV targeted drugs and new prevention and control strategies.