Abstract: In order to explore phenotypic correlations of growth performance and blood variables with RFI in growing meat rabbits, and to provide theoretical guidance for RFI breeding, a total of 110 35-day-old weaned Wannan yellow rabbits（half male and half female） were selected for the experiment after 30 days of preliminary test period. A formal experiment was conducted at 65 days of age and initial body weight was measured. The daily feed dosage and remaining amount were recorded, and the experiment lasted for 30 days. Final body weight was measured at the end of the experiment, and metabolic body weight(MBW^0.75), daily feed intake（ADFI）, feed conversion efficiency（FCR） and daily gain（ADG） were calculated. RFI values of each individual were calculated and sorted. Blood samples were collected from 4 female rabbits in the high RFI group（HRFI） and the low RFI group（LRFI）,respectively, and were used to determine the serum biochemical indexes. The results show that the RFI was significantly positively correlated with ADFI, while it was not significantly correlated with initial body weight, final body weight, ADG and MBW^0.75.The ALT, AST, GLU and TG in the high RFI group were significantly higher than those in the low RFI group. The CHO and HDL contents in the high RFI group were significantly lower than those in the low RFI group. The RFI level was significantly positively correlated（P＜0.05） with GLU（r=0.630） and TG（r=0.620） content, and were significantly positively correlated with UREA nitrogen content（r=-0.730）（P＜0.01）.The results indicated that the residual feed intake traits did not affect the growth trait of Wannan yellow rabbits. Serum GLU, TG and UREA might be candidates for the selection of RFI in Wannan yellow rabbits.